Simmons enjoyed a stellar career in franchise cricket, too, representing several teams like Mumbai Indians, Trinbago Knight Riders, Karachi Kings and Sylhet Sunrisers. He is the highest run-getter in CPL history, with 2629 runs from 91 innings, including 20 centuries. He also helped Mumbai to two IPL trophies, in 2015 and 2017, scoring a total of 1079 runs from 29 innings during his time with the franchise.